About University of Arizona Cancer Center and Associated Biorepositories

University of Arizona Cancer Center

The AZCC Biorepository is managed by TACMASR (Tissue Acquisition and Cellular/Molecular Biology Shared Resource), which is responsible for the collection and banking of biospecimens from consented UACC patients who are undergoing surgical procedures at the Banner-University Medical Center (BUMC). Biospecimens from the following organ systems are currently being banked: gynecologic, breast, prostate, endocrine, lung and GI. The Biospecimen Oversight Committee is responsible for the overall management and utilization of repository material. Preparation of specimens for use by UACC investigators and their collaborators is handled as a routine request through TACMASR, and is charged accordingly.

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The Cancer Prevention & Control (CPC) Biorepository collected and archived biospecimens from routine screening colonoscopies and a variety of prevention-related studies. Annotated dysplastic and normal specimens are present in the Biorepository. When requesting biospecimens, it is recommended to either design a small feasibility (pilot) study to demonstrate measurement precision, sensitivity and reproducibility or provide such data to support the actual conduct of the proposed project and avert biospecimen loss. The specific aims of the Colon Cancer Prevention Program Project Grant (CCPP) and previously approved projects have priority for CCPP biospecimens. If the project request is approved, the requestor must obtain and provide a signed copy of the IRB approval (or exception) document, a copy of HIPAA approval (or exception) document and a letter of agreement for the transfer of material(s). ALL unused biospecimen material must be destroyed or returned to the CPC Biorepository. The Colon Cancer Prevention Program Project Grant (NCI/NIH P01 CA41105) must be acknowledged in any publications and all reprints must be provided to the CPC Biorepository. The three colon cancer prevention studies have ended. Please contact TACMASR regarding the process for requesting access to these samples.

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The GI SPORE Biorepository collected and archived tissue and blood biospecimens from routine GI-related surgical procedures. Annotated tumor and non-tumor specimens are present in the Biorepository. Biospecimen requests are reviewed by the GI SPORE Steering Committee. When requesting biospecimens, it is recommended to either design a small feasibility (pilot) study to demonstrate measurement precision, sensitivity and reproducibility or provide such data to support the actual conduct of the proposed project and avert biospecimen loss. The specific aims of the GI SPORE grant and previously approved projects have priority for GI SPORE biospecimens. If the project request is approved, the requestor must obtain and provide a signed copy of the IRB approval (or exception) document, a copy of HIPAA approval (or exception) document and a letter of agreement for the transfer of material(s). ALL unused biospecimen material must be destroyed or returned to the GI SPORE Biorepository. The University of Arizona GI SPORE (P50 CA95060) must be acknowledged in any publications and all reprints must be provided to the GI SPORE Biorepository. This grant ran from 2002 and closed in 2014. Collection of GI specimens continues under the UACC Biorepository's consent process. Please contact TACMASR regarding the process for requesting access to these samples.

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The Skin Biorepository consists of specimens from the Skin Cancer Institute Patient Registry and Tissue Bank (SCPR-TB) and the Skin Cancer Prevention Program Biorepository (SCPP-BR). The SCPR-TB collects annotated biological specimens from patients with non-melanoma skin cancers (NMSC), malignant melanomas, and pre-malignant lesions. The SCPP-BR contains specimens from skin cancer prevention studies. Any study seeking access to tissue or information in the Skin Biorepository must have approval from the UA Institutional Review Board and the respective committees (SCPR-TB or SCPP-BR). The specific aims of the SCPP-BR and previously approved projects have priority for the specimens.

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The Arizona Lymphoma Repository collects and banks specimens from tissue and blood acquired from patients with hematopoietic malignancies, mainly lymphoma, treated at the University of Arizona Cancer Center. Tumor and non-tumor specimens are present in the repository.

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The Neurosurgery Biorepository collects and banks brain tissue specimens and blood from patients for the purpose of studying potentials biomarkers (e.g. Nagalase) for brain tumors.

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The Prostate Biorepository consists of data and specimens collected from the following: 1) Survivorship Prostate Project - a group of patients operated on by the same surgeon and analyzed by the same pathologist, 2) Prospective Patient Project - a group of patients followed by the same urologist and 3) Prostate Cancer Prevention Program (PCPP) - three patient groups enrolled on prior prostate cancer prevention studies including watchful waiting patients, pre-prostatectomy patients, and patients at high risk for prostate cancer diagnosis. Any study seeking access to tissue or information in the Prostate Biorepository must have approval from the UA Institutional Review Board and the respective committees.